Primary aldosteronism is characterized by inappropriate overproduction of the adrenal mineralocorticoid aldosterone resulting in high blood pressure, electrolyte disturbances and high cardiovascular morbidity. Using high throughput (HT) functional assays, namely HT intracellular Ca2+ imaging and HT automated patch clamp, we aim at contributing novel therapeutic approaches to treat primary aldosteronism.

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Beuschlein F, Boulkroun S, Osswald A, Wieland T, Nielsen HN, Lichtenauer UD, Penton D, Schack VR, Amar L, Fischer E, Walther A, Tauber P, Schwarzmayr T, Diener S, Graf E, Allolio B, Samson-Couterie B, Benecke A, Quinkler M, Fallo F, Plouin PF, Mantero F, Meitinger T, Mulatero P, Jeunemaitre X, Warth R, Vilsen B, Zennaro MC, Strom TM, Reincke M (2013). Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension.
Nat Genet, 45(4):440-4.

Tauber P, Penton D, Stindl J, Humberg E, Tegtmeier I, Sterner C, Beuschlein F, Reincke M, Barhanin J, Bandulik S, Warth R (2014). Pharmacology and pathophysiology of mutated KCNJ5 found in adrenal aldosterone-producing adenomas. Endocrinology, 155(4):1353-62.

Penton D, Czogalla J, Loffing J (2015). Dietary potassium and the renal control of salt balance and blood pressure. Pflugers Arch, 467(3):513-30.